![]() The first coronavirus disease 2019 (COVID-19) vaccines available in the United States were messenger RNA (mRNA) vaccines: BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna). ![]() However, more longitudinal follow-up, including follow-up of large numbers of women vaccinated earlier in pregnancy, is necessary to inform maternal, pregnancy, and infant outcomes. Preliminary findings did not show obvious safety signals among pregnant persons who received mRNA Covid-19 vaccines. Among 221 pregnancy-related adverse events reported to the VAERS, the most frequently reported event was spontaneous abortion (46 cases). Adverse neonatal outcomes included preterm birth (in 9.4%) and small size for gestational age (in 3.2%) no neonatal deaths were reported.Īlthough not directly comparable, calculated proportions of adverse pregnancy and neonatal outcomes in persons vaccinated against Covid-19 who had a completed pregnancy were similar to incidences reported in studies involving pregnant women that were conducted before the Covid-19 pandemic. Among 3958 participants enrolled in the v-safe pregnancy registry, 827 had a completed pregnancy, of which 115 (13.9%) resulted in a pregnancy loss and 712 (86.1%) resulted in a live birth (mostly among participants with vaccination in the third trimester). Injection-site pain was reported more frequently among pregnant persons than among nonpregnant women, whereas headache, myalgia, chills, and fever were reported less frequently. 28, 2021, a research team used data from the “v-safe after vaccination health checker” surveillance system, the v-safe pregnancy registry, and the Vaccine Adverse Event Reporting System (VAERS) to characterize that mRNA Covid-19 vaccine is safe in pregnancy, according to an article released by The New England Journal of Medicine.Ī total of 35,691 v-safe participants 16 to 54 years of age identified as pregnant. ![]()
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